What's in the Bag is a game that debuted in the American revival series of Whose Line.
In this game, three performers (always Wayne Brady, Colin Mochrie, and Ryan Stiles) act out a normal scene. The catch is, two handbags or purses are borrowed from audience members, and items found inside are used as props. Sunglasses and water are frequently used as part of gags in this game.
In one playing, Ryan mistakes pills for candy, and has to retrieve everything that fell on the ground after the scene is over. In another infamous playing, Ryan had sprayed (unbeknownst to him) pepper spray from one of the bags a few feet from in front of him; He didn't realize it was pepper spray until too late, when his eyes start water and started choking (and laughing at the same time).
US Season 9: 1, 7, 8, 10, and 11.
US Season 10: 11, 21